Advance Your Research with Custom Nucleic Acid Solutions

Whether you need research-grade oligos with complex modifications or GMP mRNA for clinical trials, we deliver the quality and reliability to power your scientific breakthroughs.

ISO 9001:2015 & ISO 13485:2016 Certified | GMP & research-grade options | Proven reliability

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RiboBio Impact

20+
Years Experienced Team & Experts
1M+
Oligos Delivered
800+kg
Yearly Capacity
200+
Chemical Modifications & Conjugations
Global
Customer Base
130
Bases in Length Synthesized
300+
CDMO Projects Completed
250+
Highly Trained Scientists & Project Managers

Custom Product Categories

Custom DNA Synthesis
High-quality DNA oligos for your critical research needs. Our rigorous QC process ensures sequence accuracy for your primers and gene fragments. Get detailed quality reports and expert synthesis support from our dedicated technical team.
Custom RNA Synthesis
Reliable RNA oligos synthesized in our RNase-free facility. Each batch undergoes comprehensive stability testing and comes with detailed QC documentation. Perfect for siRNA studies, mRNA research, and therapeutic development projects.
ASO
Advance your gene regulation research with our custom ASOs. Benefit from our expertise in chemical modifications for enhanced stability and cellular uptake. Includes complimentary design consultation to optimize your sequences.
CpG ODN
Support your immunotherapy research with high-purity CpG ODNs. Choose from validated sequence classes or custom designs for your specific applications. Each batch includes endotoxin testing certification for your peace of mind.
LNA (Locked Nucleic Acid)
Enhance your oligonucleotide performance with LNA modifications. Ideal for challenging targets requiring improved binding affinity and biological stability. Our team helps you optimize modification patterns for your application.
Aptamers
Expand your molecular recognition toolkit with custom aptamers. A cost-effective alternative to antibodies with excellent batch consistency. Our selection platform helps you develop aptamers for your specific targets.
Decoy Nucleic Acids
Fine-tune transcription factor activity with proven decoy designs. Our optimization process ensures stability and cellular accessibility. Comprehensive documentation and technical support for your research.
Probes & Specialized Products
Elevate your detection assays with our specialized probes. From FRET pairs to molecular beacons, get expert assistance selecting the right modifications for your application. Spectral data and technical documentation can be provided.
Discovery
Development
Commercialization
RiboBio is Your One-stop Solution for Oligonucleotide and mRNA Therapeutics

RiboBio Advantage – CDMO Capabilities

Advanced Synthesis Platforms

State-of-the-art oligonucleotide synthesis platform featuring leading OligoProcess 1800mmol synthesizer and comprehensive AKTA purification systems for precision manufacturing, up to 4,000L/Hour of purification processing.

Quality Control Systems

Advanced analytical platform with high-throughput 2-D LC-MS, UPLC, and Q-TOF systems, backed by over 20 years of expertise and validated nucleic acid testing methodologies

Production Capacity

Industry-leading manufacturing capacity of 800+ kg/year, with scalable production from micrograms to kilograms per batch, supported by AI-backed advanced monitoring and quality control systems

Quality & Compliance Standards

Our GMP manufacturing facility, certified to ISO and ICH Q7 standards and holding an NMPA drug production license, is fully compliant with global pharmaceutical regulations, consistently meeting or surpassing the stringent quality standards of ICH, US-FDA, EU-EMA, China-NMPA, and additional customer requirements.

Oligonucleotide and mRNA Platform

Oligonucleotide and mRNA Platform

from Discovery to Commercial

mRNA

  • Nucleoside/Nucleotide
  • mRNA NTP/Capping Reagent
  • Reporter Gene mRNA
  • Genome Editing mRNA
  • Gene Replacement mRNA
  • Antigen mRNA
  • Other (Wild type/Chemically modified mRNA)

Oligonucleotide

  • DNA
  • RNA
  • siRNA
  • ASO
  • crRNA/tracrRNA
  • MicroRNA
  • Aptamer
  • CpG ODN
  • Other

Conjugate

  • Oligonucleotide-GalNAc
  • Oligonucleotide-lipid
  • Oligonucleotide-Peptide
  • Oligonucleotide-Fluorescent label
  • Oligonucleotide-Cholesterol
  • Other

Advanced Oligonucleotide Modifications

RiboBio offers a comprehensive suite of chemical modification technologies, empowering your research from cellular experiments to clinical trials. Our expertise enables precise customization for enhanced stability, targeting efficiency, and therapeutic potential.

Internal Modifications
DNA nucleotides (A, T, C, G)
RNA nucleotides (A, U, C, G)
2′ O-methyl RNA (A, U, C, G)
2′-fluoro RNA nucleotides
Phosphorothioated DNA/RNA
2′ MOE RNA
LNA nucleotides
Mixed base DNA combinations
5′ Modifications
Fluorescent Labels (Cy3, Cy5, FAM)
Biotin Modifications
Thiol and Amino Modifications
Alexa Fluor NHS Esters
Spacer Modifications
Specialty Modifications (Cholesterol, VitaminE)
3′ Modifications
Terminal Modifications (Inverted dT)
Fluorescent Labels (TAMARA, Cy3, Cy5)
Biotin and Amino Modifications
Alexa Fluor Series
Quencher Modifications
Specialty Modifications (Cholesterol)

Multiple Purification Options

Choose from our range of purification methods to match your specific research requirements:

  • Standard Purification: Ideal for routine applications
  • PAGE Purification: Superior purity for demanding experiments
  • HPLC Purification: Highest grade purification for critical applications

Ready to Optimize Your Research?

Our team of experts is ready to help you select the perfect modifications for your specific application. Get personalized recommendations and technical support through our free consultation service.

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